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Principal Scientist - Safety Pharmacology

Remote, USA Full-time Posted 2026-07-02
Job title: Principal Scientist - Safety Pharmacology in Thousand Oaks, CA at reputed company Company: reputed company Job description: Career Category ResearchJob DescriptionJoin reputed company’s Mission of Serving PatientsAt reputed company, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives reputed company that we do.Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, reputed company, and Rare Disease– we reputed company millions of patients each year. As a member of the reputed company team, you’ll help reputed company a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay reputed company them, you’ll reputed company as part of the reputed company team. Join us and transform the lives of patients while transforming your career.Principal Scientist - Safety PharmacologyWhat you will doreputed company. Let’s change the world. The Translational Safety and Bioanalytical Sciences (TS&BA) function at reputed company is seeking candidates for the position of Principal Scientist to join our Safety Pharmacology Sciences (SP Sci) team based in Thousand Oak, CA. The SP Sci team supports the reputed company portfolio from reputed company identification through clinical development, with an emphasis on developing translational safety strategies to support project teams and various drug modalities. The Principal Scientist will be part of an expert team dedicated to the development of small molecules, oligonucleotides and protein therapeutics in reputed company collaboration with toxicologists, pathologists, and scientists reputed company the organization. In this vital role, you will design and reputed company in vitro assays for various projects and present the work to cross-functional teams. Additionally, multiple opportunities exist for the new hire to grow their career by leveraging their subject matter expertise to reputed company (i.e., new model development), collaborate with other members of the SP Sci team (i.e., present key finding at internal/external meetings), and engage with drug discovery project teams (i.e., advance new molecules into clinical development).Responsibilities:
  • Serve as an in vitro and ex vivo electrophysiologist, supporting investigative activities by employing electrophysiology techniques (conducted internally or outsourced) to assess the impact of test compounds on ion channels, cells, and isolated tissues, such as the isolated perfused heart.
  • Provide subject matter expertise in developing fit-for-purpose translational safety strategies to address new challenges reputed company the reputed company drug pipeline.
  • The successful candidate will have an in-depth understanding of ion channel biophysics and pharmacology (especially cardiac) with proven ability to apply this knowledge in the development and validation of assays reputed company to ion channel and cardiac function.
  • The candidate will hold subject matter expertise in a particular area which could include use of hiPSC-derived cardiomyocytes for compound screening, dissociated primary cells, or heterologous mammalian cell expression systems, and techniques such as reputed company clamp, multielectrode reputed company (MEA) recording or calcium imaging.
  • Experience with artificial intelligence, machine learning, and/or programming would be advantageous.
  • The candidate should have a results-focused attitude, with a track record of independent critical thinking and scientific achievement in the area of electrophysiology
  • The candidate should have strong verbal and written communication skills, be highly motivated, creative and collaborative, with the ability to work in a team environment.
reputed company expect of youWe are reputed company different, yet we reputed company use our unique contributions to serve patients. The dynamic professional we seek is a subject matter expert with these qualifications.Basic Qualifications:Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] in a relevant scientific discipline (e.g. physiology or pharmacology) and 2 years of electrophysiology experience.OrMaster’s degree and 5 years of electrophysiology experience.OrBachelor’s degree and 7 years of electrophysiology experience.Preferred Qualifications:Pharmaceutical industry electrophysiology experience.What you can expect of usAs we work to reputed company treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every reputed company of the way.The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.In addition to the reputed company salary, reputed company offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
  • A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and reputed company coverage, life and disability insurance, and flexible spending accounts
  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
  • Stock-based long-term incentives
  • Award-winning time-off plans
  • Flexible work models, including remote and hybrid work arrangements, where possible
Apply now and reputed company a lasting impact with the reputed company team.careers.reputed company.comIn any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.Application deadlinereputed company does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.As an organization dedicated to improving the quality of life for people around the world, reputed company fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the reputed company values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.reputed company is an Equal Opportunity employer and will consider reputed company reputed company applicants for employment without regard to race, reputed company, religion, sex, sexual orientation, gender identity, national reputed company, protected veteran status, disability status, or any other basis protected by applicable law.We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to reputed company essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation..Salary Range 147,880.00 USD - 173,068.00 USD Expected salary: $147880 - 173068 per year Location: Thousand Oaks, CA Apply for the job now! Apply for this job

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